Detecting explosive-device emplacement at multiple granularities

This paper appeared in the Proceedings of the Military Sensing Society (MSS) National Symposium, Las Vegas, Nevada, U.S., July 2010.We report on experiments with a nonimaging sensor network for detection of suspicious behavior related to pedestrian emplacement of IEDs. Emplacement is the time when detection is the most feasible for IEDs since it almost necessarily must involve some unusual behaviors. Sensors at particularly dangerous locations such as bridges, culverts, road narrowings, and road intersections could provide early warning of such activity. Imaging for surveillance has weaknesses in its susceptibility to occlusion, problems operating at night, sensitivity to angle of view, high processing requirements, and need to invade privacy. Our approach is to use a variety of nonimaging sensors with different modalities to track people. We particularly look for clues as to accelerations since these are often associated with suspicious behavior. Our approach involves preanalyzing terrain for the probability of emplacement of an IED, then combining this with real-time assessment of suspicious behavior obtained from probabilities of location derived from sensor data. We describe some experiments with a prototype sensor network and the promising results obtained.supported by the U.S. National Science Foundation under grant 0729696 of the EXP ProgramApproved for public release; distribution is unlimited

Deficiency of Foxp3+ Regulatory T Cells Exacerbates Autoimmune Arthritis by Altering the Synovial Proportions of CD4+ T Cells and Dendritic Cells

Background CD4+Fop3+ regulatory T cells (Tregs) are needed to maintain peripheral tolerance, but their role in the development of autoimmune arthritis is still debated. The present study was undertaken to investigate the mechanism by which Tregs influence autoimmune arthritis, using a mouse model entitled K/BxN.Methods We generated Treg-deficient K/BxNsf mice by congenically crossing K/BxN mice with Foxp3 mutant scurfy mice. The arthritic symptoms of the mice were clinically and histopathologically examined. The proportions and activation of CD4+ T cells and/or dendritic cells were assessed in the spleens, draining lymph nodes and synovial tissue of these mice. Results K/BxNsf mice exhibited earlier onset and more aggressive progression of arthritis than their K/BxN littermates. In particular, bone destruction associated with the influx of numerous RANKL+ cells into synovia was very prominent. They also contained more memory phenotype CD4+ T cells, more Th1 and Th2 cells, and fewer Th17 cells than their control counterparts. Plasmacytoid dendritic cells expressing high levels of CD86 and CD40 were elevated in the K/BxNsf synovia. Conclusion We conclude that Tregs oppose the progression of arthritis by inhibiting the development of RANKL+ cells, homeostatically proliferating CD4+ T cells, Th1, Th2 and mature plasmacytoid dendritic cells, and by inhibiting their influx into joints.We thank Drs. Diane Mathis and Doo Hyun Chung for providing KRN mice. This work was supported by National Research Foundation grant funded by the Korean government (MEST; 2009-0081790)

A Phenol-Amine Superglue Inspired by Insect Sclerotization Process

Exoskeletons of insects formed by sclerotization processes exhibit superstrong properties in moduli. Here, it is demonstrated that mimicking the sclerotization process using phenol and polyamine molecules unexpectedly results in a 100% ecofriendly, biocompatible waterborne superglue. Oxygen presented in air and dissolved in water acts as an initiator producing phenolic radical/quinone for superglue curing. Despite synthesis-free uses of water, phenol, and polyamine, its adhesion strength is comparable to commercial epoxy glue showing >6 MPa in lap shear strength. The phenol-amine superglue bonds to various substrates including ceramics, woods, fabrics, plastics, metals, and importantly biological tissues. Due to strong adhesion, the superglue effectively seals wounds within a few seconds, and, due to its waterborne nature, no harmful respiratory effect is observed because of any release of volatile organic compounds. The easy, cost-effective preparation of the phenol-amine superglue can revolutionize varieties of industrial, biomedical, daily life processes11Nsci

Förderung von Gesundheitskompetenz eine Aufgabe der Gesundheitsberufe?

This is Chapter 16 in F. Flammini (Ed.), Critical Infrastructure Protection, WIT Press, 2012, pp. 241-254.Detection of improvised explosive devices is difficult and requires a wide spectrum of strategies. Detection during emplacement is the best hope. Nonimaging sensors provide several advantages over cameras in expense, robustness, and processing simplicity for this task. We describe experiments with inexpensive commercial sensors, and show how data can be combined to provide monitoring for suspicious pedestrian behavior at a 1-10 meter scale. Our approach preanalyzes terrain to rate likelihood of emplacement. We install sensors and monitor the terrain, seeking direct clues to suspicious behavior such as loitering and odd sounds such as excavation. We also use sensor data to track people by inferring their probability distributions, and use this to detect significant accelerations and atypical velocity vectors, both of which can indicate suspicious behavior. We describe experiments we have conducted with a prototype sensor network of eight kinds of sensors, from which it appears that motion and sonar sensors are the most helpful for this task.supported by the U.S. National Science Foundation under grant 0729696 of the EXP Progra

DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells from RA patients (RA-FLS). An in vitro study using MH7A cells showed that DHA treatment induced caspase-8-dependent apoptosis in a dose-dependent manner and reduced the TNF-α-mediated induction of MMP-9 and IL-1β. DHA also induced the phosphorylation of eIF2α, the expression of the ER stress markers ATF4 and C/EBP homologous protein (CHOP), and death receptor 5 (DR5). The knockdown of CHOP or DR5 increased cell viability and reduced apoptosis in DHA-treated cells. Furthermore, the knockdown of CHOP reduced DHA-mediated DR5 expression, while the overexpression of CHOP increased DR5 expression. We also found that DHA treatment induced the accumulation of reactive oxygen species (ROS), and pretreatment with the anti-oxidant Tiron effectively abrogated not only the expression of CHOP and DR5, but also DHA-induced apoptosis. Under this condition, cell viability was increased, while PARP-1 cleavage and caspase-8 activation were reduced. All the findings were reproduced in human primary synovial cells obtained from RA patients. These results suggest that the DHA-mediated induction of ROS and CHOP induced apoptosis through the upregulation of DR5 in RA-FLSs, and that CHOP could be used as a therapy for RA

A Phenol‐Amine Superglue Inspired by Insect Sclerotization Process

Exoskeletons of insects formed by sclerotization processes exhibit superstrong properties in moduli. Here, it is demonstrated that mimicking the sclerotization process using phenol and polyamine molecules unexpectedly results in a 100% ecofriendly, biocompatible waterborne superglue. Oxygen presented in air and dissolved in water acts as an initiator producing phenolic radical/quinone for superglue curing. Despite synthesis-free uses of water, phenol, and polyamine, its adhesion strength is comparable to commercial epoxy glue showing >6 MPa in lap shear strength. The phenol-amine superglue bonds to various substrates including ceramics, woods, fabrics, plastics, metals, and importantly biological tissues. Due to strong adhesion, the superglue effectively seals wounds within a few seconds, and, due to its waterborne nature, no harmful respiratory effect is observed because of any release of volatile organic compounds. The easy, cost-effective preparation of the phenol-amine superglue can revolutionize varieties of industrial, biomedical, daily life processes11Nsciescopu